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KMID : 0364820130490040383
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Korean Journal of Microbiology
2013 Volume.49 No. 4 p.383 ~ p.390
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Characterization of Phylogenetic Incongruence among Protein Coding Genes of Vibrio Strains Pathogenic to Humans
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Zo Young-Gun
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Abstract
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Lateral gene transfer (LGT) of genes from other bacteria into Vibrio cholerae is expectable because of thepronounced natural competence of the bacterium. In this study, quantitative aspects of LGT among the three speciesof Vibrio pathogenic to humans were characterized. Genome sequences of V. cholerae N16961, V. parahaemolyticusRIMD2210633, V. vulnificus CMCP6, and Escherichia coli K12 substrain MG1655 were analyzed to determineorthologous quartets of protein coding genes present in all four genomes. Phylogenetic analyses on the quartets wereconducted to resolve vertical versus lateral patterns of gene polymorphisms based on congruence versusincongruence of phylogenetic trees. About 70% of the quartets could be resolved as either cohesive topology (75%)or LGT tree topologies (25%). The amount of LGT genes in Vibrio spp. appeared to be abnormally high for a genusand comparable to those of families. Patched distributions of LGT from different donors were observed on achromosome. In the small chromosome of V. cholerae, physical linkages among LGT loci spanned half the length ofthe chromosome. Either accumulative selection for the donor alleles in LGT or presence of large-scale LGT eventswas hypothesized. These findings warrant further studies on the nature of donor-specificity of LGT alleles and itsinfluence on evolution of Vibrio virulence to humans.
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KEYWORD
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Vibrio cholerae, Vibrio parahaemolyticus, Vibrio vulnificus, lateral gene transfer, quartet analysis
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